Camille Dandridge, Dexamethasone: Non-Opioid Analgesia for Total Joint Arthroplasties

Liang S, Xing M, Jiang S, Zou W. Effect of Intravenous Dexamethasone on Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. Pain Physician. 2022;25(2):E169-E183.

Waldron NH, Jones CA, Gan TJ, Allen TK, Habib AS. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: Systematic review and meta-analysis. British Journal of Anaesthesia. 2013;110(2):191-200. doi:10.1093/bja/aes431

Hannon CP, Fillingham YA, Mason JB, et al. The efficacy and safety of corticosteroids in total joint Arthroplasty: A direct meta-analysis. The Journal of Arthroplasty. 2022;37(10):1898-1905. doi:10.1016/j.arth.2022.03.084

Richardson AB, Bala A, Wellman SS, Attarian DE, Bolognesi MP, Grant SA. Perioperative Dexamethasone administration does not increase the incidence of postoperative infection in total hip and knee Arthroplasty: A retrospective analysis. The Journal of Arthroplasty. 2016;31(8):1784-1787. doi:10.1016/j.arth.2016.01.028 

Godshaw BM, Mehl AE, Shaffer JG, Meyer MS, Thomas LC, Chimento GF. The effects of peri-operative dexamethasone on patients undergoing total hip or knee arthroplasty: Is it safe for diabetics? The Journal of Arthroplasty. 2019;34(4):645-649. doi:10.1016/j.arth.2018.12.014 

Corcoran TB, Myles PS, Forbes AB, et al. Dexamethasone and surgical-site infection. New England Journal of Medicine. 2021;384(18):1731-1741. doi:10.1056/nejmoa2028982 

Heckmann ND, Wang JC, Piple AS, et al. Is intraoperative dexamethasone utilization associated with increased rates of periprosthetic joint infection following total joint arthroplasty? The Journal of Arthroplasty. 2023;38(2). doi:10.1016/j.arth.2022.08.028

Chan TC, Cheung CW, Wong SS, et al. Preoperative dexamethasone for pain relief after total knee arthroplasty. European Journal of Anaesthesiology. 2020;37(12):1157-1167. doi:10.1097/eja.0000000000001372 

Wu Y, Lu X, Ma Y, et al. Perioperative multiple low-dose dexamethasones improves postoperative clinical outcomes after total knee arthroplasty. BMC Musculoskeletal Disorders. 2018;19(1). doi:10.1186/s12891-018-2359-1 

Tammachote N, Kanitnate S. Intravenous dexamethasone injection reduces pain from 12 to 21 hours after total knee arthroplasty: A double-blind, randomized, placebo-controlled trial. The Journal of Arthroplasty. 2020;35(2):394-400. doi:10.1016/j.arth.2019.09.002 

Klag EA, Kuhlmann NA, Tramer JS, Franovic S, Muh SJ. Dexamethasone decreases postoperative opioid and antiemetic use in shoulder arthroplasty patients: A prospective, randomized controlled trial. Journal of Shoulder and Elbow Surgery. 2021;30(7):1544-1552. doi:10.1016/j.jse.2020.12.005 

Backes JR, Bentley JC, Politi JR, Chambers BT. Dexamethasone reduces length of hospitalization and improves postoperative pain and nausea after total joint arthroplasty. The Journal of Arthroplasty. 2013;28(8):11-17. doi:10.1016/j.arth.2013.05.041 

Gasbjerg KS, Hägi-Pedersen D, Lunn TH, et al. Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total Knee Arthroplasty: Randomised clinical trial. BMJ. Published online January 4, 2022. doi:10.1136/bmj-2021-067325 

Fan Z, Ma J, Ma X, et al. The efficacy of dexamethasone on pain and recovery after total hip arthroplasty. Medicine. 2018;97(13). doi:10.1097/md.0000000000010100 

Zhuo Y, Yu R, Wu C, Huang Y, Ye J, Zhang Y. The role of perioperative intravenous low-dose dexamethasone in rapid recovery after total knee arthroplasty: A meta-analysis. Journal of International Medical Research. 2021;49(3):030006052199822. doi:10.1177/0300060521998220 

Ruberto RA, Farah O, Lopez C, Hickernell T. Perioperative intravenous glucocorticoids in total joint arthroplasty: A systematic review. Journal of the American Academy of Orthopaedic Surgeons. 2023;31(2):e94-e106. doi:10.5435/jaaos-d-22-00232 

Samona J, Cook C, Krupa K, et al. Effect of intraoperative dexamethasone on pain scores and narcotic consumption in patients undergoing total knee arthroplasty. Orthopaedic Surgery. 2017;9(1):110-114. doi:10.1111/os.12313