Christine Rolfes, Nebulized Dexmedetomidine: Preoperative Efficacy on Tracheal Intubation

1. Antony T, Acharya K V, Rajgopal Acharya P. Effectiveness of nebulized dexmedetomidine as a premedication in flexible bronchoscopy in Indian patients -a prospective, randomized, double-blinded study. Contemp Clin Trials Commun. 2023;33:101111. doi:10.1016/j.conctc.2023.101111

2.Bonagua DM, Crisostomo HC, Hernandez AGC, Brodit SE. The effect of dexmedetomidine nebulization as a premedication prior to peripheral intravenous access in pediatric patients and its effect on separation anxiety score and acceptance to intravenous cannulation score. PACCJ. 2020;(Vol. 8, Issue 2):115-119. doi:10.14587/paccj.2020.19

3.De Cassai A, Sella N, Geraldini F, et al. Preoperative dexmedetomidine and intraoperative bradycardia in laparoscopic cholecystectomy: a meta-analysis with trial sequential analysis. Korean J Anesthesiol. 2022;75(3):245-254. doi:10.4097/kja.21359

4.Elisha S, Heiner J, Nagelhout J. Nurse Anesthesia. 7th ed. Elsevier; 2023.

5.Flood P, Rathmell J, Urman R. Stoelting’s Pharmacology & Physiology in Anesthetic Practice. 6th ed. Wolters Kluwer; 2022.

6.Grover N, Taneja R, Rashid Y, Shrivastava N. Nebulised fentanyl, dexmedetomidine and magnesium sulphate for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A double-blinded, randomised comparative study. Indian J Anaesth. 2023;67(8):730-735. doi:10.4103/ija.ija_397_22

7.Gupta M, Rohilla R, Gupta P, Tamilchelvan H, Joshi U, Kanwat J. Nebulized dexmedetomidine for attenuating hemodynamic response to laryngoscopy and endotracheal intubation in adult patients undergoing surgeries under general anaesthesia: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiol. 2023;23(1):406. doi:10.1186/s12871-023-02366-9

8.Jain K, Sethi SK, K.N. H, Patodi V, Jain N, Meena D. Efficacy of dexmedetomidine in attenuating pressor response to laryngoscopy and endotracheal intubation under bispectral index controlled anesthesia: a prospective randomized double-blinded study. Ain-Shams J Anesthesiol. 2023;15(1):15. doi:10.1186/s42077-023-00314-w

9.Kaila D, Sharma S, Mehta N, Jeelani J, Rasool W, Nazir M. Effect of pre-operative dexmedetomidine nebulisation on the hemodynamic response to laryngoscopy and intubation. International Journal of Life Sciences Beiotechnology and Pharma Research. 2023;12(1):125-131.

10.Kamal M, Agarwal D, Singariya G, Kumari K, Paliwal B, Ujwal S. Effect of dexmedetomidine on attenuation of hemodynamic response to intubation, skin incision, and sternotomy in coronary artery bypass graft patients: A double-blind randomized control trial. J Anaesthesiol Clin Pharmacol. 2020;36(2):255-260. doi:10.4103/joacp.JOACP_353_18

11.Kumar NRR, Jonnavithula N, Padhy S, Sanapala V, Naik VV. Evaluation of nebulised dexmedetomidine in blunting haemodynamic response to intubation: A prospective randomised study. Indian Journal of Anaesthesia. 2020;64(10):874. doi:10.4103/ija.IJA_235_20

12.Lin J, Wu C, Zhao D, Du X, Zhang W, Fang J. The Sedative Effects of Inhaled Nebulized Dexmedetomidine on Children: A Systematic Review and Meta-Analysis. Frontiers in Pediatrics. 2022;10. Accessed January 13, 2024. https://www.frontiersin.org/articles/10.3389/fped.2022.865107

13.Misra S, Behera BK, Mitra JK, Sahoo AK, Jena SS, Srinivasan A. Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial. Korean J Anesthesiol. 2021;74(2):150-157. doi:10.4097/kja.20153

14.Mowafy SMS, Ellatif SEA. Effectiveness of nebulized dexmedetomidine for treatment of post-dural puncture headache in parturients undergoing elective cesarean section under spinal anesthesia: a randomized controlled study. J Anesth. 2021;35(4):515-524. doi:10.1007/s00540-021-02944-6

15.Niyogi S, Biswas A, Chakraborty I, Chakraborty S, Acharjee A. Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route. Indian J Anaesth. 2019;63(11):915-923. doi:10.4103/ija.IJA_320_19

16.Paul NS, Abraham V, Liddle D. A randomized double blind study to evaluate the effect of nebulized dexmedetomidine on the haemodynamic response to laryngoscopy – Intubation and intubation conditions. IJCA. 2023;10(4):358-364. doi:10.18231/j.ijca.2023.075

17.Praveen R, Sethuraman M, Vimala S, et al. A prospective-randomized placebo-controlled trial comparing the effects of nebulized dexmedetomidine v/s dexmedetomidine-lignocaine mixture on intraoperative hemodynamics and surgical field quality in patients undergoing endoscopic transnasal transsphenoidal pituitary tumor surgery. Surg Neurol Int. 2023;14:431. doi:10.25259/SNI_858_2023

18.Sancheti AG, Swami SS, Konnur SL, Amin N. A Comparative Study between Local Dexmedetomidine and Intravenous Dexmedetomidine during Awake Fiberoptic Nasotracheal Intubation. Anesthesia Essays and Researches. 2022;16(3):407. doi:10.4103/aer.aer_140_22

19.Shereef KM, Chaitali B, Swapnadeep S, Gauri M. Role of nebulised dexmedetomidine, midazolam or ketamine as premedication in preschool children undergoing general anaesthesia—A prospective, double-blind, randomised study. Indian J Anaesth. 2022;66(Suppl 4):S200-S206. doi:10.4103/ija.ija_931_21

20.Sheth DrPA, Hathiwala DrH, Shah DrD. Effect of dexmedetomidine by nebulizer for blunting stress response to direct laryngoscopy and intubation. Int J Med Anesthesiology. 2021;4(4):76-80. doi:10.33545/26643766.2021.v4.i4b.326

21.Singh V, Pahade A, Mowar A. Comparison of Intravenous Versus Nebulized Dexmedetomidine for Laryngoscopy and Intubation-Induced Sympathoadrenal Stress Response Attenuation. Anesth Pain Med. 2022;12(5). doi:10.5812/aapm-132607

22.Sriramka B, Awal S, Mallik D, Narayan J. Nebulised dexmedetomidine for patient’s comfort and satisfaction during diagnostic upper gastrointestinal endoscopy: A double-blind randomised controlled study. Indian J Anaesth. 2023;67(9):825-827. doi:10.4103/ija.ija_393_23

23.Suryawanshi DC, Ravindran DDG, Sathvika DP, Jawale DR. Efficacy Of Preoperative Dexmedetomidine Nebulization On Blunting The Hemodynamic Response To Laryngoscopy And Intubation. Journal of Pharmaceutical Negative Results. Published online December 31, 2022:4196-4205.
24. Zhao W, Li J, Wang N, et al. Effect of dexmedetomidine on postoperative nausea and vomiting in patients under general anaesthesia: an updated meta-analysis of randomised controlled trials. BMJ Open. 2023;13(8):e067102. doi:10.1136/bmjopen-2022-067102